Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a pathogenetic role in C3G. However, alternative pathway...

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Bibliographic Details
Main Authors: Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
C3 glomerulopathy
membranoproliferative glomerulonephritis
complement alternative pathway
C3 nephritic factors
terminal complement complex
C3 convertase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02329/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02329/full

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