The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1

The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1

Abstract Background In the course of replication of eukaryotic chromosomes, the telomere length is maintained due to activity of telomerase, the ribonucleoprotein reverse transcriptase. Abolishing telomerase function causes progressive shortening of telomeres and, ultimately, cell cycle arrest and r...

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Main Authors: Alexey V. Beletsky, Alexander N. Malyavko, Maria V. Sukhanova, Eugenia S. Mardanova, Maria I. Zvereva, Olga A. Petrova, Yulia Yu. Parfenova, Maria P. Rubtsova, Andrey V. Mardanov, Olga I. Lavrik, Olga A. Dontsova, Nikolai V. Ravin
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Genomics
Subjects:
Telomerase
Senescence
Yeast
Hansenula polymorpha
RNA-seq
DNA repair
Online Access:http://link.springer.com/article/10.1186/s12864-017-3889-x

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http://link.springer.com/article/10.1186/s12864-017-3889-x

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