Sleep disorders and gout in Australian adults

Abstract Background The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and patient reported sleep outcomes. Methods A cross-sectional national onlin...

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Main Authors: Julia New-Tolley, Amy C. Reynolds, Sarah L. Appleton, Tiffany K. Gill, Susan Lester, Robert J. Adams, Catherine L. Hill
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Rheumatology
Subjects:
Online Access:https://doi.org/10.1186/s41927-021-00199-y
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spelling doaj-a65e093c320f4b04af408893d9b737172021-08-29T11:28:16ZengBMCBMC Rheumatology2520-10262021-08-01511710.1186/s41927-021-00199-ySleep disorders and gout in Australian adultsJulia New-Tolley0Amy C. Reynolds1Sarah L. Appleton2Tiffany K. Gill3Susan Lester4Robert J. Adams5Catherine L. Hill6Rheumatology Unit, The Queen Elizabeth HospitalFlinders Health and Medical Research Institute (Sleep Health)/Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders UniversityFlinders Health and Medical Research Institute (Sleep Health)/Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders UniversityAdelaide Medical School, University of AdelaideRheumatology Unit, The Queen Elizabeth HospitalFlinders Health and Medical Research Institute (Sleep Health)/Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders UniversityRheumatology Unit, The Queen Elizabeth HospitalAbstract Background The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and patient reported sleep outcomes. Methods A cross-sectional national online survey of a representative sample of Australian adults > 18 years assessed self-reported doctor-diagnosed OSA, insomnia and patient reported sleep outcomes. Possible undiagnosed OSA was estimated using self-reported frequent loud snoring and witnessed apnoeas. Participants self-reported physician-diagnosed gout and other health conditions. Multivariable logistic regression analyses were performed for both objectives. Odds ratios with 95% confidence intervals were reported. Results There were 1948 participants of whom 126 (6.5%) had gout and 124 (6.4%) had diagnosed sleep apnoea. After adjusting for age, body mass index (BMI), sex, alcohol intake and the presence of arthritis, those with obstructive sleep apnoea diagnosed on polysomnography were twice as likely to report having gout compared to those without. (OR = 2.6, 95% CI 1.5–4.6). Additionally, participants with symptoms suggestive of sleep apnoea were also twice as likely to have gout compared to those without (OR = 2.8, 95%CI 1.6–5.1). There was also a higher likelihood of restless legs syndrome, insomnia and worry about sleep in patients with gout. Conclusion Diagnosed and suspected OSA are associated with higher likelihood of gout. Participants with gout are also more likely to report suffering from restless legs syndrome, insomnia and worry about their sleep. Given the morbidity associated with sleep problems, we should be vigilant regarding sleep health in our patients with gout.https://doi.org/10.1186/s41927-021-00199-yGoutSleep Apnoea, obstructiveSleep hygieneSleep disorders
collection DOAJ
language English
format Article
sources DOAJ
author Julia New-Tolley
Amy C. Reynolds
Sarah L. Appleton
Tiffany K. Gill
Susan Lester
Robert J. Adams
Catherine L. Hill
spellingShingle Julia New-Tolley
Amy C. Reynolds
Sarah L. Appleton
Tiffany K. Gill
Susan Lester
Robert J. Adams
Catherine L. Hill
Sleep disorders and gout in Australian adults
BMC Rheumatology
Gout
Sleep Apnoea, obstructive
Sleep hygiene
Sleep disorders
author_facet Julia New-Tolley
Amy C. Reynolds
Sarah L. Appleton
Tiffany K. Gill
Susan Lester
Robert J. Adams
Catherine L. Hill
author_sort Julia New-Tolley
title Sleep disorders and gout in Australian adults
title_short Sleep disorders and gout in Australian adults
title_full Sleep disorders and gout in Australian adults
title_fullStr Sleep disorders and gout in Australian adults
title_full_unstemmed Sleep disorders and gout in Australian adults
title_sort sleep disorders and gout in australian adults
publisher BMC
series BMC Rheumatology
issn 2520-1026
publishDate 2021-08-01
description Abstract Background The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and patient reported sleep outcomes. Methods A cross-sectional national online survey of a representative sample of Australian adults > 18 years assessed self-reported doctor-diagnosed OSA, insomnia and patient reported sleep outcomes. Possible undiagnosed OSA was estimated using self-reported frequent loud snoring and witnessed apnoeas. Participants self-reported physician-diagnosed gout and other health conditions. Multivariable logistic regression analyses were performed for both objectives. Odds ratios with 95% confidence intervals were reported. Results There were 1948 participants of whom 126 (6.5%) had gout and 124 (6.4%) had diagnosed sleep apnoea. After adjusting for age, body mass index (BMI), sex, alcohol intake and the presence of arthritis, those with obstructive sleep apnoea diagnosed on polysomnography were twice as likely to report having gout compared to those without. (OR = 2.6, 95% CI 1.5–4.6). Additionally, participants with symptoms suggestive of sleep apnoea were also twice as likely to have gout compared to those without (OR = 2.8, 95%CI 1.6–5.1). There was also a higher likelihood of restless legs syndrome, insomnia and worry about sleep in patients with gout. Conclusion Diagnosed and suspected OSA are associated with higher likelihood of gout. Participants with gout are also more likely to report suffering from restless legs syndrome, insomnia and worry about their sleep. Given the morbidity associated with sleep problems, we should be vigilant regarding sleep health in our patients with gout.
topic Gout
Sleep Apnoea, obstructive
Sleep hygiene
Sleep disorders
url https://doi.org/10.1186/s41927-021-00199-y
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