Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK3/6/p38MAPK and MEK1/2/ERK1/2 Signalling Pathways

Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK3/6/p38MAPK and MEK1/2/ERK1/2 Signalling Pathways

Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to osmoregulation in fish. Using goldfish as a model,...

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Bibliographic Details
Main Authors: Aifen Yan, Yanfeng Chen, Shuang Chen, Shuisheng Li, Yong Zhang, Jirong Jia, Hui Yu, Lian Liu, Fang Liu, Chaoqun Hu, Dongsheng Tang, Ting Chen
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
goldfish
leptin
prolactin
pituitary
expression regulation
signal pathway
Online Access:https://www.mdpi.com/1422-0067/18/12/2781

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