Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.

Bibliographic Details
Main Authors:	Dmitrii A. Aksenov, Nikolai A. Arutiunov, Vladimir V. Maliuga, Alexander V. Aksenov, Michael Rubin
Format:	Article
Language:	English
Published:	Beilstein-Institut 2020-11-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	cyclization heterocycles imidazo[1,5-a]pyridines nitroalkanes polyphosphoric acid
Online Access:	https://doi.org/10.3762/bjoc.16.239

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spelling	doaj-a6c0f2f18ecd423ab672834f224571162021-04-02T19:06:28ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972020-11-011612903291010.3762/bjoc.16.2391860-5397-16-239Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanesDmitrii A. Aksenov0Nikolai A. Arutiunov1Vladimir V. Maliuga2Alexander V. Aksenov3Michael Rubin4Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian FederationDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian FederationDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian FederationDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian FederationDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian FederationImidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.https://doi.org/10.3762/bjoc.16.239cyclizationheterocyclesimidazo[1,5-a]pyridinesnitroalkanespolyphosphoric acid
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dmitrii A. Aksenov Nikolai A. Arutiunov Vladimir V. Maliuga Alexander V. Aksenov Michael Rubin
spellingShingle	Dmitrii A. Aksenov Nikolai A. Arutiunov Vladimir V. Maliuga Alexander V. Aksenov Michael Rubin Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes Beilstein Journal of Organic Chemistry cyclization heterocycles imidazo[1,5-a]pyridines nitroalkanes polyphosphoric acid
author_facet	Dmitrii A. Aksenov Nikolai A. Arutiunov Vladimir V. Maliuga Alexander V. Aksenov Michael Rubin
author_sort	Dmitrii A. Aksenov
title	Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
title_short	Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
title_full	Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
title_fullStr	Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
title_full_unstemmed	Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
title_sort	synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2020-11-01
description	Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.
topic	cyclization heterocycles imidazo[1,5-a]pyridines nitroalkanes polyphosphoric acid
url	https://doi.org/10.3762/bjoc.16.239
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Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

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