Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.

Bibliographic Details
Main Authors: Dmitrii A. Aksenov, Nikolai A. Arutiunov, Vladimir V. Maliuga, Alexander V. Aksenov, Michael Rubin
Format: Article
Language:English
Published: Beilstein-Institut 2020-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cyclization
heterocycles
imidazo[1,5-a]pyridines
nitroalkanes
polyphosphoric acid
Online Access:https://doi.org/10.3762/bjoc.16.239

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