Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer

Abstract Background The conversion from estrogen-dependent to estrogen-independent state of ER+ breast cancer cells is the key step to promote resistance to endocrine therapies. Although the crucial role of MAPK/ERK signaling pathway in estrogen-independent breast cancer cell growth is well establis...

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Bibliographic Details
Main Authors: Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong, Yin-Yuan Mo
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Cancer
Subjects:
ERK
Online Access:http://link.springer.com/article/10.1186/s12943-017-0727-3