Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat

Using a viral vector for mutant (P301L) tau, we studied the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons. The mutant tau vector caused progressive loss of pars compacta dopaminergic neurons over time, reduced striatal d...

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Bibliographic Details
Main Authors: Ronald L. Klein, Robert D. Dayton, Wen-Lang Lin, Dennis W. Dickson
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Adeno-associated virus
α-Synuclein
Neurodegeneration
Neurofibrillary tangles
Substantia nigra
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000458

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http://www.sciencedirect.com/science/article/pii/S0969996105000458

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