A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S....

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Bibliographic Details
Main Authors: Duy Pham Thanh, Abhilasha Karkey, Sabina Dongol, Nhan Ho Thi, Corinne N Thompson, Maia A Rabaa, Amit Arjyal, Kathryn E Holt, Vanessa Wong, Nga Tran Vu Thieu, Phat Voong Vinh, Tuyen Ha Thanh, Ashish Pradhan, Saroj Kumar Shrestha, Damoder Gajurel, Derek Pickard, Christopher M Parry, Gordon Dougan, Marcel Wolbers, Christiane Dolecek, Guy E Thwaites, Buddha Basnyat, Stephen Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
fluoroquinolones
randomised controlled trial
typhoid fever
nepal
treatment failure
H58
Online Access:https://elifesciences.org/articles/14003

Internet

https://elifesciences.org/articles/14003

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