Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Abstract To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rare familial cases of AD can occur due to dominant mutations in a small number of ge...

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Bibliographic Details
Main Authors: Karissa Barthelson, Stephen Martin Pederson, Morgan Newman, Michael Lardelli
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Brain
Subjects:
Familial Alzheimer’s disease
SORL1
RNA-seq
Zebrafish
Mitochondria
Iron homeostasis
Online Access:http://link.springer.com/article/10.1186/s13041-020-00681-7

Internet

http://link.springer.com/article/10.1186/s13041-020-00681-7

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