The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial

Background: Bacterial vaginosis (BV) is the most prevalent causes of abnormal secre-tion in women at fertility age. Also, Bacterial vaginosis is one of the most common dis-eases in women who refer to gynecology clinic. The main cause of the pathogenesis is increasing pH of vagina due to reduced numb...

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Main Authors: Soror Roozafzay, Khadijeh Hekmat, Kobra Shojaei, Pourandokht Afshari, Mohammad Bahadoram
Format: Article
Language:fas
Published: Tehran University of Medical Sciences 2014-08-01
Series:Tehran University Medical Journal
Subjects:
Online Access:http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5227&slc_lang=en&sid=1
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spelling doaj-a7840fe835684c0d8a0c09e834c3bf7a2020-11-24T23:45:48ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-08-01725286293The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trialSoror Roozafzay 0Khadijeh Hekmat 1Kobra Shojaei 2Pourandokht Afshari 3Mohammad Bahadoram 4 Department of Midwifery, Repro-ductive Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Midwifery, Repro-ductive Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Cen-ter, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran. Department of Midwifery, Repro-ductive Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Student Research Committee, Ah-vaz Jundishapur University of Medical Sciences (AJUMS), Ah-vaz, Iran. Background: Bacterial vaginosis (BV) is the most prevalent causes of abnormal secre-tion in women at fertility age. Also, Bacterial vaginosis is one of the most common dis-eases in women who refer to gynecology clinic. The main cause of the pathogenesis is increasing pH of vagina due to reduced number of lactobacillus and growth of anaero-bic bacteria. Prevalence of BV varies between 10 to 30 percent in different societies. Amsel criteria is used as diagnostic test in BV. This interventional study was designed to assess the impact of vaginal lactobacillus suppository and metronidazole compared to metronidazole alone on the recovery and recurrence of bacterial vaginosis. Methods: This study was a prospective, randomized, double-blind clinical trial which was conducted on 130 women with bacterial vaginosis to compare the effects of vagi-nal lactobacillus suppository and metronidazole. Bacterial vaginosis was diagnosed us-ing Amsel criteria that based on some clinical symptoms. Patients were divided into two groups, first group were treated with oral metronidazole plus lactobacillus and second group were treated with metronidazole alone. Patients were followed-up one week and four weeks after initiation of the treatment. Results: One hundred and thirty women completed the study. Patients were followed at one and four weeks after initiation of intervention. Amsel criteria and recovery rate in both groups compared before treatment one and four weeks after treatment. The crite-ria and treatment were significantly improved, but this improvement was higher and statistically significant in the metronidazole plus Lactobacillus group compared to sec-ond group (P< 0.0001). Conclusion: The protective effects of lactobacillus in dealing with anaerobic patho-gens as well as the negative impact of metronidazole on lactobacillus of vaginal flora, use of lactobacillus along with metronidazole especially in patients with recurrent infec-tions is recommended. In other words, using lactobacillus with metronidazole for treatment of bacterial vaginosis is more effective than metronidazole alone. http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5227&slc_lang=en&sid=1bacterial vaginosis double-blind method lactobacillus metronidazole
collection DOAJ
language fas
format Article
sources DOAJ
author Soror Roozafzay
Khadijeh Hekmat
Kobra Shojaei
Pourandokht Afshari
Mohammad Bahadoram
spellingShingle Soror Roozafzay
Khadijeh Hekmat
Kobra Shojaei
Pourandokht Afshari
Mohammad Bahadoram
The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
Tehran University Medical Journal
bacterial vaginosis
double-blind method
lactobacillus
metronidazole
author_facet Soror Roozafzay
Khadijeh Hekmat
Kobra Shojaei
Pourandokht Afshari
Mohammad Bahadoram
author_sort Soror Roozafzay
title The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
title_short The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
title_full The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
title_fullStr The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
title_full_unstemmed The effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
title_sort effects of lactobacillus suppositories in the recovery and recur-rence of bacterial vaginosis: a double-blind randomized clinical trial
publisher Tehran University of Medical Sciences
series Tehran University Medical Journal
issn 1683-1764
1735-7322
publishDate 2014-08-01
description Background: Bacterial vaginosis (BV) is the most prevalent causes of abnormal secre-tion in women at fertility age. Also, Bacterial vaginosis is one of the most common dis-eases in women who refer to gynecology clinic. The main cause of the pathogenesis is increasing pH of vagina due to reduced number of lactobacillus and growth of anaero-bic bacteria. Prevalence of BV varies between 10 to 30 percent in different societies. Amsel criteria is used as diagnostic test in BV. This interventional study was designed to assess the impact of vaginal lactobacillus suppository and metronidazole compared to metronidazole alone on the recovery and recurrence of bacterial vaginosis. Methods: This study was a prospective, randomized, double-blind clinical trial which was conducted on 130 women with bacterial vaginosis to compare the effects of vagi-nal lactobacillus suppository and metronidazole. Bacterial vaginosis was diagnosed us-ing Amsel criteria that based on some clinical symptoms. Patients were divided into two groups, first group were treated with oral metronidazole plus lactobacillus and second group were treated with metronidazole alone. Patients were followed-up one week and four weeks after initiation of the treatment. Results: One hundred and thirty women completed the study. Patients were followed at one and four weeks after initiation of intervention. Amsel criteria and recovery rate in both groups compared before treatment one and four weeks after treatment. The crite-ria and treatment were significantly improved, but this improvement was higher and statistically significant in the metronidazole plus Lactobacillus group compared to sec-ond group (P< 0.0001). Conclusion: The protective effects of lactobacillus in dealing with anaerobic patho-gens as well as the negative impact of metronidazole on lactobacillus of vaginal flora, use of lactobacillus along with metronidazole especially in patients with recurrent infec-tions is recommended. In other words, using lactobacillus with metronidazole for treatment of bacterial vaginosis is more effective than metronidazole alone.
topic bacterial vaginosis
double-blind method
lactobacillus
metronidazole
url http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5227&slc_lang=en&sid=1
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