Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients
Background. Long-term outcomes (mortality and health-related quality of life) of sepsis have risen as important indicators for health care. Pulmonary infection and abdominal infection are the leading causes of sepsis. However, few researches about long-term outcomes focused on the origin of sepsis....
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2016/4213712 |
id |
doaj-a7957f7ea28a4ee592c7225194fd01d2 |
---|---|
record_format |
Article |
spelling |
doaj-a7957f7ea28a4ee592c7225194fd01d22020-11-24T22:42:25ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/42137124213712Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis PatientsXiao-Li He0Xue-Lian Liao1Zhi-Chao Xie2Li Han3Xiao-Lei Yang4Yan Kang5Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaBackground. Long-term outcomes (mortality and health-related quality of life) of sepsis have risen as important indicators for health care. Pulmonary infection and abdominal infection are the leading causes of sepsis. However, few researches about long-term outcomes focused on the origin of sepsis. Here we aim to study the clinical differences between pulmonary-sepsis and abdominal-sepsis and to investigate whether different infection foci were associated with long-term outcomes. Methods. Patients who survived after hospital discharge were followed up by telephone interview. Quality of life (QoL) was assessed using the EuroQol 5-dimension (EQ5D) questionnaire. Results. Four hundred and eighty-three sepsis patients were included, 272 (56.3%) had pulmonary-sepsis, and 180 (37.3%) had abdominal-sepsis. The overall ICU and one-year mortality rates of the cohort were 17.8% and 36.1%, respectively. Compared with abdominal-sepsis, pulmonary-sepsis patients had older age, higher APACHE II, higher ICU mortality (31.7% versus 12.6%), and one-year mortality (45.4% versus 24.4%), together with worse QoL. Age, septic shock, acute renal failure, fungus infection, anion gap, and pulmonary infection were predictors for one-year mortality and pulmonary infection was a risk factor for poor QoL. Conclusions. Pulmonary-sepsis showed worse outcome than abdominal-sepsis. Pulmonary infection is a risk factor for one-year mortality and QoL after sepsis.http://dx.doi.org/10.1155/2016/4213712 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Li He Xue-Lian Liao Zhi-Chao Xie Li Han Xiao-Lei Yang Yan Kang |
spellingShingle |
Xiao-Li He Xue-Lian Liao Zhi-Chao Xie Li Han Xiao-Lei Yang Yan Kang Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients BioMed Research International |
author_facet |
Xiao-Li He Xue-Lian Liao Zhi-Chao Xie Li Han Xiao-Lei Yang Yan Kang |
author_sort |
Xiao-Li He |
title |
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients |
title_short |
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients |
title_full |
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients |
title_fullStr |
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients |
title_full_unstemmed |
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients |
title_sort |
pulmonary infection is an independent risk factor for long-term mortality and quality of life for sepsis patients |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Background. Long-term outcomes (mortality and health-related quality of life) of sepsis have risen as important indicators for health care. Pulmonary infection and abdominal infection are the leading causes of sepsis. However, few researches about long-term outcomes focused on the origin of sepsis. Here we aim to study the clinical differences between pulmonary-sepsis and abdominal-sepsis and to investigate whether different infection foci were associated with long-term outcomes. Methods. Patients who survived after hospital discharge were followed up by telephone interview. Quality of life (QoL) was assessed using the EuroQol 5-dimension (EQ5D) questionnaire. Results. Four hundred and eighty-three sepsis patients were included, 272 (56.3%) had pulmonary-sepsis, and 180 (37.3%) had abdominal-sepsis. The overall ICU and one-year mortality rates of the cohort were 17.8% and 36.1%, respectively. Compared with abdominal-sepsis, pulmonary-sepsis patients had older age, higher APACHE II, higher ICU mortality (31.7% versus 12.6%), and one-year mortality (45.4% versus 24.4%), together with worse QoL. Age, septic shock, acute renal failure, fungus infection, anion gap, and pulmonary infection were predictors for one-year mortality and pulmonary infection was a risk factor for poor QoL. Conclusions. Pulmonary-sepsis showed worse outcome than abdominal-sepsis. Pulmonary infection is a risk factor for one-year mortality and QoL after sepsis. |
url |
http://dx.doi.org/10.1155/2016/4213712 |
work_keys_str_mv |
AT xiaolihe pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients AT xuelianliao pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients AT zhichaoxie pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients AT lihan pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients AT xiaoleiyang pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients AT yankang pulmonaryinfectionisanindependentriskfactorforlongtermmortalityandqualityoflifeforsepsispatients |
_version_ |
1725700124117565440 |