Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Rett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough bu...

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Bibliographic Details
Main Authors: Catarina Miranda-Lourenço, Sofia T. Duarte, Cátia Palminha, Cláudia Gaspar, Tiago M. Rodrigues, Teresa Magalhães-Cardoso, Nádia Rei, Mariana Colino-Oliveira, Rui Gomes, Sara Ferreira, Jéssica Rosa, Sara Xapelli, Judith Armstrong, Àngels García-Cazorla, Paulo Correia-de-Sá, Ana M. Sebastião, Maria José Diógenes
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
Brain-derived neurotrophic factor
TrkB receptors
Adenosinergic system
Mecp2 knockout model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303181

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http://www.sciencedirect.com/science/article/pii/S0969996120303181

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