Familial Papillary Thyroid Carcinoma: A Retrospective Analysis
Background. Whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members, we pe...
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doaj-a7c1b461064a445f92abcd4302582d3d2020-11-24T23:47:35ZengHindawi LimitedJournal of Oncology1687-84501687-84692011-01-01201110.1155/2011/948786948786Familial Papillary Thyroid Carcinoma: A Retrospective AnalysisThomas J. McDonald0Albert A. Driedger1Bertha M. Garcia2Stanislaus H. M. Van Uum3Irina Rachinsky4Vijaya Chevendra5Daniel Breadner6Richard Feinn7Stephen J. Walsh8Carl D. Malchoff9Department of Medicine, University of Western Ontario London, ON, N6A 5A5, CanadaDepartment of Nuclear Medicine, University of Western Ontario London, ON, N6A 4S2, CanadaDepartment of Pathology, University of Western Ontario London, ON, N6A 5A5, CanadaDepartment of Medicine, University of Western Ontario London, ON, N6A 5A5, CanadaDepartment of Nuclear Medicine, University of Western Ontario London, ON, N6A 4S2, CanadaDepartment of Medicine, University of Western Ontario London, ON, N6A 5A5, CanadaDepartment of Medicine, University of Western Ontario London, ON, N6A 5A5, CanadaDepartment of Medicine, University of Connecticut Health Centre, Farmington, CT 06107, USADepartment of Medicine, University of Connecticut Health Centre, Farmington, CT 06107, USADepartment of Medicine, University of Connecticut Health Centre, Farmington, CT 06107, USABackground. Whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members, we performed a chi square by trend analysis on our patients clinical and pathologic data comparing: first degree families with three or more affected members versus first degree families with two affected members versus sporadic cases of papillary thyroid carcinoma. Results. No statistically significant trends were seen for any presenting surgical pathology parameter, age at presentation, length of follow-up or gender distribution. The familial groups exhibited significant trends for higher rates of reoperation (P=0.05) and/or requiring additional radioactive iodine therapy (P=0.03), distant metastases (P=0.003) and deaths (P=0.01). These aggressive features were most apparent in certain families with three or more affected members. Conclusions. Using the chi square by trend analysis, a significant trend was seen for the familial form of papillary thyroid cancer to possess more aggressive features than the sporadic disease. Prompt recognition of the familial nature of the disease may provide earlier diagnosis and treatment in similarly affected family members.http://dx.doi.org/10.1155/2011/948786 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas J. McDonald Albert A. Driedger Bertha M. Garcia Stanislaus H. M. Van Uum Irina Rachinsky Vijaya Chevendra Daniel Breadner Richard Feinn Stephen J. Walsh Carl D. Malchoff |
spellingShingle |
Thomas J. McDonald Albert A. Driedger Bertha M. Garcia Stanislaus H. M. Van Uum Irina Rachinsky Vijaya Chevendra Daniel Breadner Richard Feinn Stephen J. Walsh Carl D. Malchoff Familial Papillary Thyroid Carcinoma: A Retrospective Analysis Journal of Oncology |
author_facet |
Thomas J. McDonald Albert A. Driedger Bertha M. Garcia Stanislaus H. M. Van Uum Irina Rachinsky Vijaya Chevendra Daniel Breadner Richard Feinn Stephen J. Walsh Carl D. Malchoff |
author_sort |
Thomas J. McDonald |
title |
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis |
title_short |
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis |
title_full |
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis |
title_fullStr |
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis |
title_full_unstemmed |
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis |
title_sort |
familial papillary thyroid carcinoma: a retrospective analysis |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2011-01-01 |
description |
Background. Whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members, we performed a chi square by trend analysis on our patients clinical and pathologic data comparing: first degree families with three or more affected members versus first degree families with two affected members versus sporadic cases of papillary thyroid carcinoma. Results. No statistically significant trends were seen for any presenting surgical pathology parameter, age at presentation, length of follow-up or gender distribution. The familial groups exhibited significant trends for higher rates of reoperation (P=0.05) and/or requiring additional radioactive iodine therapy (P=0.03), distant metastases (P=0.003) and deaths (P=0.01). These aggressive features were most apparent in certain families with three or more affected members. Conclusions. Using the chi square by trend analysis, a significant trend was seen for the familial form of papillary thyroid cancer to possess more aggressive features than the sporadic disease. Prompt recognition of the familial nature of the disease may provide earlier diagnosis and treatment in similarly affected family members. |
url |
http://dx.doi.org/10.1155/2011/948786 |
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