Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy
Small-molecule vascular disrupting agents (VDAs) target the established tumor blood vessels, resulting in rapidly and selectively widespread ischemia and necrosis of central tumor; meanwhile, blood flow in normal tissues is relatively unaffected. Although VDAs therapy is considered an important opti...
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doaj-a818171b008f4df3bceec733ee14d6882020-11-24T23:18:58ZengElsevierJournal of the Formosan Medical Association0929-66462013-03-01112311512410.1016/j.jfma.2012.09.017Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapyXue-Yuan WuWei MaKiran GurungChi-Hua GuoSmall-molecule vascular disrupting agents (VDAs) target the established tumor blood vessels, resulting in rapidly and selectively widespread ischemia and necrosis of central tumor; meanwhile, blood flow in normal tissues is relatively unaffected. Although VDAs therapy is considered an important option for treatment, its use is still limited. The tumor cells at the periphery are less sensitive to vascular shutdown than those at the center, and subsequently avoid a nutrient-deprived environment. This phenomenon is referred to as tumor resistance to VDAs treatment. The viable periphery rim of tumor cells contributes to tumor regeneration, metastasis, and ongoing progression. However, there is no systematic review of the plausible mechanisms of repopulation of the viable tumor cells following VDAs therapy. The purpose of this review is to provide insights into mechanisms of tumor surviving small-molecule VDAs therapy, and the synergetic treatment to the remaining viable tumor cells at the periphery.http://www.sciencedirect.com/science/article/pii/S0929664612004743antiangiogenic therapytumor vasculaturevascular disrupting agent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xue-Yuan Wu Wei Ma Kiran Gurung Chi-Hua Guo |
spellingShingle |
Xue-Yuan Wu Wei Ma Kiran Gurung Chi-Hua Guo Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy Journal of the Formosan Medical Association antiangiogenic therapy tumor vasculature vascular disrupting agent |
author_facet |
Xue-Yuan Wu Wei Ma Kiran Gurung Chi-Hua Guo |
author_sort |
Xue-Yuan Wu |
title |
Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy |
title_short |
Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy |
title_full |
Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy |
title_fullStr |
Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy |
title_full_unstemmed |
Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy |
title_sort |
mechanisms of tumor resistance to small-molecule vascular disrupting agents: treatment and rationale of combination therapy |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2013-03-01 |
description |
Small-molecule vascular disrupting agents (VDAs) target the established tumor blood vessels, resulting in rapidly and selectively widespread ischemia and necrosis of central tumor; meanwhile, blood flow in normal tissues is relatively unaffected. Although VDAs therapy is considered an important option for treatment, its use is still limited. The tumor cells at the periphery are less sensitive to vascular shutdown than those at the center, and subsequently avoid a nutrient-deprived environment. This phenomenon is referred to as tumor resistance to VDAs treatment. The viable periphery rim of tumor cells contributes to tumor regeneration, metastasis, and ongoing progression. However, there is no systematic review of the plausible mechanisms of repopulation of the viable tumor cells following VDAs therapy. The purpose of this review is to provide insights into mechanisms of tumor surviving small-molecule VDAs therapy, and the synergetic treatment to the remaining viable tumor cells at the periphery. |
topic |
antiangiogenic therapy tumor vasculature vascular disrupting agent |
url |
http://www.sciencedirect.com/science/article/pii/S0929664612004743 |
work_keys_str_mv |
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1725579043041968128 |