Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocki...

Full description

Bibliographic Details
Main Authors: Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10335-5

Internet

https://doi.org/10.1038/s41467-019-10335-5

Similar Items