Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila
Control of DNA copy number is essential to maintain genome stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-domain-containing SUUR protein inhibits replication fork progression within specific regions of the genome to promote DNA underreplication. While d...
Main Authors: | Alexander Munden, Zhan Rong, Amanda Sun, Rama Gangula, Simon Mallal, Jared T Nordman |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/39140 |
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