Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Bo...

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Bibliographic Details
Main Authors: Matthew R. Broadus, Tony W. Chen, Leif R. Neitzel, Victoria H. Ng, Jeanne N. Jodoin, Laura A. Lee, Adrian Salic, David J. Robbins, Anthony J. Capobianco, James G. Patton, Stacey S. Huppert, Ethan Lee
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305149

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http://www.sciencedirect.com/science/article/pii/S2211124716305149

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