Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.

Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.

Genome-wide association studies (GWAS) and candidate gene studies have identified a number of risk loci associated with the smoking-related disease COPD, a disorder that originates in the airway epithelium. Since airway basal cell (BC) stem/progenitor cells exhibit the earliest abnormalities associa...

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Bibliographic Details
Main Authors: Dorothy M Ryan, Thomas L Vincent, Jacqueline Salit, Matthew S Walters, Francisco Agosto-Perez, Renat Shaykhiev, Yael Strulovici-Barel, Robert J Downey, Lauren J Buro-Auriemma, Michelle R Staudt, Neil R Hackett, Jason G Mezey, Ronald G Crystal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912203?pdf=render

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http://europepmc.org/articles/PMC3912203?pdf=render

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