Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...
Main Authors: | SungEun Kim, Yubin Kim, JungHo Kong, Eunjee Kim, Jae Hyeok Choi, Hyeong Dong Yuk, HyeSun Lee, Hwa-Ryeon Kim, Kyoung-Hwa Lee, Minyong Kang, Jae-Seok Roe, Kyung Chul Moon, Sanguk Kim, Ja Hyeon Ku, Kunyoo Shin |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/43024 |
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