Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II

Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II

Paracrine interactions between malignant estrogen receptor positive (ER<sup>+</sup>) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs. In breast cancer, mainly the cAMP-responsive promoter I.3/II-region mediates excessive arom...

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Bibliographic Details
Main Authors: Alexander Kaiser, Thomas Krüger, Gabriele Eiselt, Joachim Bechler, Olaf Kniemeyer, Otmar Huber, Martin Schmidt
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
breast cancer
estrogen synthesis
breast adipose fibroblasts
adipose stromal cells
epigenetics
sirt-1
parp-1
Online Access:https://www.mdpi.com/2073-4409/9/2/427

Internet

https://www.mdpi.com/2073-4409/9/2/427

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