Zelen design clinical trials: why, when, and how

Abstract Background In 1979, Marvin Zelen proposed a new design for randomized clinical trials intended to facilitate clinicians’ and patients’ participation. The defining innovation of Zelen’s proposal was random assignment of treatment prior to patient or participant consent. Following randomizati...

Full description

Bibliographic Details
Main Authors: Gregory E. Simon, Susan M. Shortreed, Lynn L. DeBar
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Trials
Subjects:
Online Access:https://doi.org/10.1186/s13063-021-05517-w