Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis
The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nu...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-08-01
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Series: | Cancers |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6694/7/3/0848 |