The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately...

Full description

Bibliographic Details
Main Authors: Katharina Helene Susek, Maria Karvouni, Evren Alici, Andreas Lundqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
chemokines
cancer immunotherapy
metastasis
NK cells
T cells
myeloid cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/full
id doaj-aa4e03f0258d4862a02516b6ca6a222e
record_format Article
spelling doaj-aa4e03f0258d4862a02516b6ca6a222e2020-11-25T00:54:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02159402002The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor MicroenvironmentKatharina Helene Susek0Maria Karvouni1Evren Alici2Evren Alici3Andreas Lundqvist4Andreas Lundqvist5Department of Medicine, Karolinska Institutet (KI), Solna, SwedenDepartment of Medicine, Karolinska Institutet (KI), Solna, SwedenDepartment of Medicine, Karolinska Institutet (KI), Solna, SwedenCell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United StatesCell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United StatesDepartment of Oncology-Pathology, Karolinska Institutet (KI), Solna, SwedenChemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches.https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/fullchemokinescancer immunotherapymetastasisNK cellsT cellsmyeloid cells
collection DOAJ
language English
format Article
sources DOAJ
author Katharina Helene Susek
Maria Karvouni
Evren Alici
Evren Alici
Andreas Lundqvist
Andreas Lundqvist
spellingShingle Katharina Helene Susek
Maria Karvouni
Evren Alici
Evren Alici
Andreas Lundqvist
Andreas Lundqvist
The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
Frontiers in Immunology
chemokines
cancer immunotherapy
metastasis
NK cells
T cells
myeloid cells
author_facet Katharina Helene Susek
Maria Karvouni
Evren Alici
Evren Alici
Andreas Lundqvist
Andreas Lundqvist
author_sort Katharina Helene Susek
title The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
title_short The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
title_full The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
title_fullStr The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
title_full_unstemmed The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
title_sort role of cxc chemokine receptors 1–4 on immune cells in the tumor microenvironment
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2018-09-01
description Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches.
topic chemokines
cancer immunotherapy
metastasis
NK cells
T cells
myeloid cells
url https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/full
work_keys_str_mv AT katharinahelenesusek theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT mariakarvouni theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT evrenalici theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT evrenalici theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT andreaslundqvist theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT andreaslundqvist theroleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT katharinahelenesusek roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT mariakarvouni roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT evrenalici roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT evrenalici roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT andreaslundqvist roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
AT andreaslundqvist roleofcxcchemokinereceptors14onimmunecellsinthetumormicroenvironment
_version_ 1725233766593462272

Similar Items