Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.

Previous genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal expansion, cortical bone mineral density (BMD(C)) cortical thickness, trabecular num...

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Bibliographic Details
Main Authors: Lavinia Paternoster, Mattias Lorentzon, Liesbeth Vandenput, Magnus K Karlsson, Osten Ljunggren, Andreas Kindmark, Dan Mellstrom, John P Kemp, Caroline E Jarett, Jeff M P Holly, Adrian Sayers, Beate St Pourcain, Nicholas J Timpson, Panos Deloukas, George Davey Smith, Susan M Ring, David M Evans, Jon H Tobias, Claes Ohlsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2987837?pdf=render

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http://europepmc.org/articles/PMC2987837?pdf=render

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