Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience
Background: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intr...
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doaj-aa81db93a95e426c90eaa5d9001c79992020-11-25T03:17:39ZengSAGE PublishingClinical Pathology2632-010X2019-09-011210.1177/2632010X19876934Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center ExperienceMaryam Zarei0Alireza Shasaeefar1Kurosh Kazemi2Masoud Dehghani3Seyed-Ali Malekhosseini4Bita Geramizadeh5Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery (Hepatobiliary), School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery (Hepatobiliary), School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery (Hepatobiliary), School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery (Hepatobiliary), School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intraductal papillary neoplasm of bile duct (IPNB). The former is flat and does not produce grossly and radiologically detectable mass lesion, but the latter produces grossly identifiable lesion. Objectives: The development of bile duct dysplasia (BilIN) in chronic biliary diseases has been investigated and proved, but the incidence of BilIN in non-biliary causes of cirrhosis such as hepatitis B and non-alcoholic steatohepatitis has very rarely been investigated. In this study, we have tried to find out the prevalence of BilIN in non-biliary cirrhosis. Patients and Methods: During the study period (2017-2018) in 100 explanted livers with the diagnosis of non-biliary cirrhosis, thorough sampling (at least 20 sections) was performed, and pathologic sections were studied for the presence of BilIN. Results: In the 100 studied livers with different diagnoses of non-biliary causes of cirrhosis, 31% of cases showed BilIN-1 and 2% of cases showed BiliIN-2. No case of BilIN-3 has been identified. Discussion and Conclusions: Non-biliary causes of cirrhosis should be considered as precursors of cholangiocarcinoma (BilIN); however, the incidence of this occurrence is low.https://doi.org/10.1177/2632010X19876934 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryam Zarei Alireza Shasaeefar Kurosh Kazemi Masoud Dehghani Seyed-Ali Malekhosseini Bita Geramizadeh |
spellingShingle |
Maryam Zarei Alireza Shasaeefar Kurosh Kazemi Masoud Dehghani Seyed-Ali Malekhosseini Bita Geramizadeh Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience Clinical Pathology |
author_facet |
Maryam Zarei Alireza Shasaeefar Kurosh Kazemi Masoud Dehghani Seyed-Ali Malekhosseini Bita Geramizadeh |
author_sort |
Maryam Zarei |
title |
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience |
title_short |
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience |
title_full |
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience |
title_fullStr |
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience |
title_full_unstemmed |
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience |
title_sort |
biliary intraepithelial neoplasia in non-biliary cirrhosis—report from 100 explanted livers: a single center experience |
publisher |
SAGE Publishing |
series |
Clinical Pathology |
issn |
2632-010X |
publishDate |
2019-09-01 |
description |
Background: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intraductal papillary neoplasm of bile duct (IPNB). The former is flat and does not produce grossly and radiologically detectable mass lesion, but the latter produces grossly identifiable lesion. Objectives: The development of bile duct dysplasia (BilIN) in chronic biliary diseases has been investigated and proved, but the incidence of BilIN in non-biliary causes of cirrhosis such as hepatitis B and non-alcoholic steatohepatitis has very rarely been investigated. In this study, we have tried to find out the prevalence of BilIN in non-biliary cirrhosis. Patients and Methods: During the study period (2017-2018) in 100 explanted livers with the diagnosis of non-biliary cirrhosis, thorough sampling (at least 20 sections) was performed, and pathologic sections were studied for the presence of BilIN. Results: In the 100 studied livers with different diagnoses of non-biliary causes of cirrhosis, 31% of cases showed BilIN-1 and 2% of cases showed BiliIN-2. No case of BilIN-3 has been identified. Discussion and Conclusions: Non-biliary causes of cirrhosis should be considered as precursors of cholangiocarcinoma (BilIN); however, the incidence of this occurrence is low. |
url |
https://doi.org/10.1177/2632010X19876934 |
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