Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)

Acute kidney injury (AKI) is a significant global health concern. The primary causes of AKI include ischemia, sepsis and nephrotoxicity. The unraveled interface between nervous system and immune response with specific focus on pain pathways is generating a huge interest in reference to AKI. The nerv...

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Main Authors: Aprajita Gupta, Dev Kumar, Sanjeev Puri, Veena Puri
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00424/full
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spelling doaj-aaa1497831f641e2824e00dccf074e942020-11-25T03:57:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-08-01710.3389/fmed.2020.00424496672Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)Aprajita Gupta0Dev Kumar1Sanjeev Puri2Veena Puri3Centre for Systems Biology & Bioinformatics, Panjab University, Chandigarh, IndiaDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Biotechnology, University Institute of Engineering and Technology, Panjab University, Chandigarh, IndiaCentre for Systems Biology & Bioinformatics, Panjab University, Chandigarh, IndiaAcute kidney injury (AKI) is a significant global health concern. The primary causes of AKI include ischemia, sepsis and nephrotoxicity. The unraveled interface between nervous system and immune response with specific focus on pain pathways is generating a huge interest in reference to AKI. The nervous system though static executes functions by nerve fibers throughout the body. Neuronal peptides released by nerves effect the immune response to mediate the hemodynamic system critical to the functioning of kidney. Pain is the outcome of cellular cross talk between nervous and immune systems. The widespread release of neuropeptides, neurotransmitters and immune cells contribute to bidirectional neuroimmune cross talks for pain manifestation. Recently, we have reported pain pathway genes that may pave the way to better understand such processes during AKI. An auxiliary understanding of the functions and communications in these systems will lead to novel approaches in pain management and treatment through the pathological state, specifically during acute kidney injury.https://www.frontiersin.org/article/10.3389/fmed.2020.00424/fullacute kidney injuryneuroinflammationpainneuropeptidesCGRPTNF-α
collection DOAJ
language English
format Article
sources DOAJ
author Aprajita Gupta
Dev Kumar
Sanjeev Puri
Veena Puri
spellingShingle Aprajita Gupta
Dev Kumar
Sanjeev Puri
Veena Puri
Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
Frontiers in Medicine
acute kidney injury
neuroinflammation
pain
neuropeptides
CGRP
TNF-α
author_facet Aprajita Gupta
Dev Kumar
Sanjeev Puri
Veena Puri
author_sort Aprajita Gupta
title Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
title_short Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
title_full Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
title_fullStr Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
title_full_unstemmed Neuroimmune Mechanisms in Signaling of Pain During Acute Kidney Injury (AKI)
title_sort neuroimmune mechanisms in signaling of pain during acute kidney injury (aki)
publisher Frontiers Media S.A.
series Frontiers in Medicine
issn 2296-858X
publishDate 2020-08-01
description Acute kidney injury (AKI) is a significant global health concern. The primary causes of AKI include ischemia, sepsis and nephrotoxicity. The unraveled interface between nervous system and immune response with specific focus on pain pathways is generating a huge interest in reference to AKI. The nervous system though static executes functions by nerve fibers throughout the body. Neuronal peptides released by nerves effect the immune response to mediate the hemodynamic system critical to the functioning of kidney. Pain is the outcome of cellular cross talk between nervous and immune systems. The widespread release of neuropeptides, neurotransmitters and immune cells contribute to bidirectional neuroimmune cross talks for pain manifestation. Recently, we have reported pain pathway genes that may pave the way to better understand such processes during AKI. An auxiliary understanding of the functions and communications in these systems will lead to novel approaches in pain management and treatment through the pathological state, specifically during acute kidney injury.
topic acute kidney injury
neuroinflammation
pain
neuropeptides
CGRP
TNF-α
url https://www.frontiersin.org/article/10.3389/fmed.2020.00424/full
work_keys_str_mv AT aprajitagupta neuroimmunemechanismsinsignalingofpainduringacutekidneyinjuryaki
AT devkumar neuroimmunemechanismsinsignalingofpainduringacutekidneyinjuryaki
AT sanjeevpuri neuroimmunemechanismsinsignalingofpainduringacutekidneyinjuryaki
AT veenapuri neuroimmunemechanismsinsignalingofpainduringacutekidneyinjuryaki
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