Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague- Dawley rats were used and classified into three groups: a group intrapleurally injecte...
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doaj-aab7ac5213994dc7a94910e404ec13f52021-10-02T07:35:38ZengDe GruyterOpen Medicine2391-54632015-09-0110110.1515/med-2015-0051med-2015-0051Efficacy of mistletoe for chemical pleurodesis in rats without malignancyAhn Hyo Yeong0Cho Jeong Su1Kim Yeong Dae2I Hoseok3Kim Yeon Ji4Kim Ahrong5Lee Chang Hun6Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaDepartment of Pathology, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of KoreaChemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague- Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME.http://www.degruyter.com/view/j/med.2015.10.issue-1/med-2015-0051/med-2015-0051.xml?format=INTchemical pleurodesis mistletoe extraction animals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahn Hyo Yeong Cho Jeong Su Kim Yeong Dae I Hoseok Kim Yeon Ji Kim Ahrong Lee Chang Hun |
spellingShingle |
Ahn Hyo Yeong Cho Jeong Su Kim Yeong Dae I Hoseok Kim Yeon Ji Kim Ahrong Lee Chang Hun Efficacy of mistletoe for chemical pleurodesis in rats without malignancy Open Medicine chemical pleurodesis mistletoe extraction animals |
author_facet |
Ahn Hyo Yeong Cho Jeong Su Kim Yeong Dae I Hoseok Kim Yeon Ji Kim Ahrong Lee Chang Hun |
author_sort |
Ahn Hyo Yeong |
title |
Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
title_short |
Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
title_full |
Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
title_fullStr |
Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
title_full_unstemmed |
Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
title_sort |
efficacy of mistletoe for chemical pleurodesis in
rats without malignancy |
publisher |
De Gruyter |
series |
Open Medicine |
issn |
2391-5463 |
publishDate |
2015-09-01 |
description |
Chemical pleurodesis is an effective treatment
modality to reduce recurrence of malignant effusion.
Several agents have been used in chemical pleurodesis
but, it is not yet clear which is better. Eighteen Sprague-
Dawley rats were used and classified into three groups:
a group intrapleurally injected normal saline (group A,
n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe
extraction (ME) (group C, n=6). Autopsy was performed to
evaluate the pleural adhesion, pathologic examination of
pleura and lung and bronchoalveolar lavage fluid analysis
4 weeks after pleurodesis. Both group B and C showed an
obvious pleural adhesion and there was no significant difference
in grade of pleural adhesion between two groups
(p=0.58). The parietal pleural thickness in talc group than
ME group was significantly thicker (p=0.002) and the visceral
pleura of talc group showed marked foreign body
reaction with fibrosis and many multinucleated giant
cells associated with talc crystal. This study suggests that
pleurodesis using ME in condition without malignancy
has comparable effect to pleurodesis using talc. However,
additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy
of pleurodesis using ME. |
topic |
chemical pleurodesis mistletoe extraction animals |
url |
http://www.degruyter.com/view/j/med.2015.10.issue-1/med-2015-0051/med-2015-0051.xml?format=INT |
work_keys_str_mv |
AT ahnhyoyeong efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT chojeongsu efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT kimyeongdae efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT ihoseok efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT kimyeonji efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT kimahrong efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy AT leechanghun efficacyofmistletoeforchemicalpleurodesisinratswithoutmalignancy |
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1716857465927106560 |