Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

Background/Aims: Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/type I interferon (IFN) pathways plays a pivotal role...

Full description

Bibliographic Details
Main Authors: Tadaatsu Imaizumi, Ryo Hayakari, Shojiro Watanabe, Tomomi Aizawa, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shogo Kawaguchi, Hiroshi Tanaka
Format: Article
Language:English
Published: Karger Publishers 2017-11-01
Series:Kidney & Blood Pressure Research
Subjects:
Cyld
Lupus nephritis
MDA5
Mesangial cells
RIG-I
TLR3
Online Access:https://www.karger.com/Article/FullText/485084

Internet

https://www.karger.com/Article/FullText/485084

Similar Items