Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Targeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune re...

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Main Authors:	Jing Qi, Feiyang Jin, Yuchan You, Yan Du, Di Liu, Xiaoling Xu, Jun Wang, Luwen Zhu, Minjiang Chen, Gaofeng Shu, Liming Wu, Jiansong Ji, Yongzhong Du
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24902-2

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spelling	doaj-abce4ae1a7124d5ebad9a32c2e0500b42021-08-08T11:37:02ZengNature Publishing GroupNature Communications2041-17232021-08-0112111710.1038/s41467-021-24902-2Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micellesJing Qi0Feiyang Jin1Yuchan You2Yan Du3Di Liu4Xiaoling Xu5Jun Wang6Luwen Zhu7Minjiang Chen8Gaofeng Shu9Liming Wu10Jiansong Ji11Yongzhong Du12Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityTargeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses.https://doi.org/10.1038/s41467-021-24902-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jing Qi Feiyang Jin Yuchan You Yan Du Di Liu Xiaoling Xu Jun Wang Luwen Zhu Minjiang Chen Gaofeng Shu Liming Wu Jiansong Ji Yongzhong Du
spellingShingle	Jing Qi Feiyang Jin Yuchan You Yan Du Di Liu Xiaoling Xu Jun Wang Luwen Zhu Minjiang Chen Gaofeng Shu Liming Wu Jiansong Ji Yongzhong Du Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles Nature Communications
author_facet	Jing Qi Feiyang Jin Yuchan You Yan Du Di Liu Xiaoling Xu Jun Wang Luwen Zhu Minjiang Chen Gaofeng Shu Liming Wu Jiansong Ji Yongzhong Du
author_sort	Jing Qi
title	Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
title_short	Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
title_full	Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
title_fullStr	Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
title_full_unstemmed	Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
title_sort	synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	Targeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses.
url	https://doi.org/10.1038/s41467-021-24902-2
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Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

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