An Attenuated Escherichia coli K88ac LT(S63K)ΔSTb Efficiently Provides Protection Against Enterotoxigenic Escherichia coli in the Mouse Model

An Attenuated Escherichia coli K88ac LT(S63K)ΔSTb Efficiently Provides Protection Against Enterotoxigenic Escherichia coli in the Mouse Model

To develop an attenuated vaccine candidate against K88ac enterotoxigenic Escherichia coli (ETEC), a novel Escherichia coli (E. coli) K88ac LT(S63K)ΔSTb with LT(S63K) mutation and ST1 deletion was generated using site mutagenesis and λ-Red homologous recombination based on wild paternal ETEC strain C...

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Bibliographic Details
Main Authors: Xinyu Zhang, Shupei Yu, Darong Cheng, Yu Feng, Yuefei Yang, Huaichang Sun, Jiabo Ding, Fang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Veterinary Science
Subjects:
ETEC
K88ac
LT(S63K)
STb deletion
attenuation
protection
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.620255/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2020.620255/full

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