A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.

Bibliographic Details
Main Authors: Navid Madani, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A. Zhao, Brandon P. Conn, Todd Bradley, M. Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F. Haynes, Amos B. Smith III, Sampa Santra, Joseph Sodroski
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04758-9

Internet

https://doi.org/10.1038/s41467-018-04758-9

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