Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers

Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers

Permeability enhancers are receiving increased attention arising from their ability to increase transepithelial permeability and thus, bioavailability of orally or pulmonary administered biopharmaceutics. Here we present the synthesis and the in vitro assaying of a series of lactose-based non-ionic...

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Bibliographic Details
Main Authors: Simone Lucarini, Laura Fagioli, Robert Cavanagh, Wanling Liang, Diego Romano Perinelli, Mario Campana, Snjezana Stolnik, Jenny K. W. Lam, Luca Casettari, Andrea Duranti
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceutics
Subjects:
absorption enhancers
sugar-based surfactants
biocompatibility studies
transmucosal drug delivery
Online Access:http://www.mdpi.com/1999-4923/10/3/81

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http://www.mdpi.com/1999-4923/10/3/81

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