Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats

Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats

Abstract Background Previous study showed that purinergic P2X7 receptors (P2X7R) reach the highest expression in the first week after unilateral ureteral obstruction (UUO) in mice, and are involved in the process of inflammation, apoptosis and fibrosis of renal tissue. We, herein, document the role...

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Bibliographic Details
Main Authors: José Monteiro Sad Pereira, André Luis Barreira, Conrado Rodrigues Gomes, Felipe Mateus Ornellas, Débora Santos Ornellas, Luiz Carlos Miranda, Lucio Ronaldo Cardoso, Robson Coutinho-Silva, Alberto Schanaider, Marcelo M. Morales, Maurilo Leite, Christina Maeda Takiya
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Nephrology
Subjects:
Renal inflammation
P2X7 receptor
Unilateral ureteral obstruction
Macrophages
Online Access:http://link.springer.com/article/10.1186/s12882-020-01861-2

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http://link.springer.com/article/10.1186/s12882-020-01861-2

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