Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism.

Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism.

Congenital hyperinsulinism (CHI) is characterised by inappropriate insulin secretion causing profound hypoglycaemia and brain damage if inadequately controlled. Pancreatic tissue isolated from patients with diffuse CHI shows abnormal proliferation rates, the mechanisms of which are not fully resolve...

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Bibliographic Details
Main Authors: Sophie G Kellaway, Karolina Mosinska, Zainaba Mohamed, Alexander Ryan, Stephen Richardson, Melanie Newbould, Indraneel Banerjee, Mark J Dunne, Karen E Cosgrove
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222350

Internet

https://doi.org/10.1371/journal.pone.0222350

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