Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells

Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells

The 18 kDa translocator protein (TSPO) plays an important role in apoptotic cell death, including apoptosis induced by the hypoxia mimicking agent cobalt chloride (CoCl<sub>2</sub>). In this study, the protective effects of a high (CB86; Ki= 1.6 nM) and a low (CB204; Ki= 117.7 nM) affini...

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Bibliographic Details
Main Authors: Nidal Zeineh, Nunzio Denora, Valentino Laquintana, Massimo Franco, Abraham Weizman, Moshe Gavish
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomedicines
Subjects:
translocator protein (TSPO)
CoCl2
mitochondrial membrane potential
reactive oxygen species (ROS)
cell viability
cell death
Online Access:https://www.mdpi.com/2227-9059/8/5/106

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https://www.mdpi.com/2227-9059/8/5/106

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