Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide adenine dinucleotide phosphate (NADPH), we examined h...

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Bibliographic Details
Main Authors: Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
6PGD
pentose phosphate pathway
effector T cells
metabolism
reactive oxygen species
tumor immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001455

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http://www.sciencedirect.com/science/article/pii/S2211124721001455

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