Dense deposit disease involving C3 and C4d Deposits

Dense deposit disease involving C3 and C4d Deposits

Dense deposit disease (DDD), earlier called Type II membranoproliferative glomerulonephritis is distinct disease having frequent relapses reaching end-stage kidney disease by 10-year in up to 50%–60% of cases and high recurrence rate in the allograft. The term DDD is derived from its distinctive rib...

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Bibliographic Details
Main Authors: M Vankalakunti, R Augustine, R Jangamani, V Siddini, R Bonu, K Babu, S H Ballal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Indian Journal of Nephrology
Subjects:
Complement C3/C4d
dense deposit disease
electron microscope
membranoproliferative glomerulonephritis
Online Access:http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2018;volume=28;issue=1;spage=61;epage=64;aulast=Vankalakunti
Description
Summary:Dense deposit disease (DDD), earlier called Type II membranoproliferative glomerulonephritis is distinct disease having frequent relapses reaching end-stage kidney disease by 10-year in up to 50%–60% of cases and high recurrence rate in the allograft. The term DDD is derived from its distinctive ribbon-like osmiophilic deposits in the lamina densa of glomerular basement membrane by electron microscopy. Pathogenetically, alternate pathway dysfunction leads to this disease, which is diagnosed by ultrastructure. Herein, we describe our observation of C4d positivity in an adolescent boy with DDD.
ISSN:0971-4065
1998-3662

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