Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants

Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants

Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain.Methods: We performed two studies in southern coastal...

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Bibliographic Details
Main Authors: Nicole U. Stoffel, Mary A. Uyoga, Francis M. Mutuku, Joe N. Frost, Edith Mwasi, Daniela Paganini, Fiona R. M. van der Klis, Indu J. Malhotra, A. Desiráe LaBeaud, Cristian Ricci, Simon Karanja, Hal Drakesmith, Charles H. King, Michael B. Zimmermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
iron deficiency
anemia
iron
vaccine response
seroconversion
infancy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01313/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01313/full

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