Innovative HBV Animal Models Based on the Entry Receptor NTCP
Hepatitis B is a major global health problem, with an estimated 257 million chronically infected patients and almost 1 million deaths per year. The causative agent is hepatitis B virus (HBV), a small, enveloped, partially double-stranded DNA virus. HBV has a strict species specificity, naturally inf...
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doaj-ad75613b4b4b473d97cc28c1806436c92020-11-25T01:25:45ZengMDPI AGViruses1999-49152020-07-011282882810.3390/v12080828Innovative HBV Animal Models Based on the Entry Receptor NTCPJochen M. Wettengel0Benjamin J. Burwitz1Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstr. 30, 81675 Munich, GermanyVaccine & Gene Therapy Institute, Oregon Health & Science University, 505 N.W. 185th Avenue Beaverton, Tanasbourne, OR 97006, USAHepatitis B is a major global health problem, with an estimated 257 million chronically infected patients and almost 1 million deaths per year. The causative agent is hepatitis B virus (HBV), a small, enveloped, partially double-stranded DNA virus. HBV has a strict species specificity, naturally infecting only humans and chimpanzees. Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter expressed on hepatocytes, has been shown to be one of the key factors in HBV infection, playing a crucial role in the HBV entry process in vitro and in vivo. Variations in the amino acid sequence of NTCP can inhibit HBV infection and, therefore, contributes, in part, to the species barrier. This discovery has revolutionized the search for novel animal models of HBV. Indeed, it was recently shown that variations in the amino acid sequence of NTCP represent the sole species barrier for HBV infection in macaques. Here, we review what is known about HBV entry through the NTCP receptor and highlight how this knowledge has been harnessed to build new animal models for the study of HBV pathogenesis and curative therapies.https://www.mdpi.com/1999-4915/12/8/828sodium taurocholate co-transporting polypeptidehepatitis B virusrhesus macaqueanimal model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jochen M. Wettengel Benjamin J. Burwitz |
spellingShingle |
Jochen M. Wettengel Benjamin J. Burwitz Innovative HBV Animal Models Based on the Entry Receptor NTCP Viruses sodium taurocholate co-transporting polypeptide hepatitis B virus rhesus macaque animal model |
author_facet |
Jochen M. Wettengel Benjamin J. Burwitz |
author_sort |
Jochen M. Wettengel |
title |
Innovative HBV Animal Models Based on the Entry Receptor NTCP |
title_short |
Innovative HBV Animal Models Based on the Entry Receptor NTCP |
title_full |
Innovative HBV Animal Models Based on the Entry Receptor NTCP |
title_fullStr |
Innovative HBV Animal Models Based on the Entry Receptor NTCP |
title_full_unstemmed |
Innovative HBV Animal Models Based on the Entry Receptor NTCP |
title_sort |
innovative hbv animal models based on the entry receptor ntcp |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2020-07-01 |
description |
Hepatitis B is a major global health problem, with an estimated 257 million chronically infected patients and almost 1 million deaths per year. The causative agent is hepatitis B virus (HBV), a small, enveloped, partially double-stranded DNA virus. HBV has a strict species specificity, naturally infecting only humans and chimpanzees. Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter expressed on hepatocytes, has been shown to be one of the key factors in HBV infection, playing a crucial role in the HBV entry process in vitro and in vivo. Variations in the amino acid sequence of NTCP can inhibit HBV infection and, therefore, contributes, in part, to the species barrier. This discovery has revolutionized the search for novel animal models of HBV. Indeed, it was recently shown that variations in the amino acid sequence of NTCP represent the sole species barrier for HBV infection in macaques. Here, we review what is known about HBV entry through the NTCP receptor and highlight how this knowledge has been harnessed to build new animal models for the study of HBV pathogenesis and curative therapies. |
topic |
sodium taurocholate co-transporting polypeptide hepatitis B virus rhesus macaque animal model |
url |
https://www.mdpi.com/1999-4915/12/8/828 |
work_keys_str_mv |
AT jochenmwettengel innovativehbvanimalmodelsbasedontheentryreceptorntcp AT benjaminjburwitz innovativehbvanimalmodelsbasedontheentryreceptorntcp |
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