Four promoters of IRF5 respond distinctly to stimuli and are affected by autoimmune-risk polymorphisms

Four promoters of IRF5 respond distinctly to stimuli and are affected by autoimmune-risk polymorphisms

Introduction: Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis affect millions of people worldwide. Interferon regulatory factor 5 (IRF5) contains polymorphisms associated with these autoimmune diseases. Two of these functional polymorphisms are f...

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Bibliographic Details
Main Authors: Daniel N. Clark, R. Daniel Read, Vera eMayhew, Stephen C. Petersen, Lissenya B. Argueta, Lance A. Stutz, Rodney E. Till, Sean M. Bergsten, Brandon S. Robinson, Douglas G. Baumann, J. Casey Heap, Brian D. Poole
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
interferon
systemic lupus erythematosus
IRF5
Alternative promoters
Autoimmune diseas risk
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00360/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00360/full

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