Temporal changes of Sall4 lineage contribution in developing embryos and the contribution of Sall4-lineages to postnatal germ cells in mice

Abstract Mutations in the SALL4 gene cause human syndromes with defects in multiple organs. Sall4 expression declines rapidly in post-gastrulation mouse embryos, and our understanding of the requirement of Sall4 in animal development is still limited. To assess the contributions of Sall4 expressing...

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Bibliographic Details
Main Authors: Naoyuki Tahara, Hiroko Kawakami, Teng Zhang, David Zarkower, Yasuhiko Kawakami
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-018-34745-5