Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS

Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS

Abstract Background The development of new therapeutic strategies to treat amyotrophic lateral sclerosis (ALS) is of utmost importance. The use of cyclic nitroxides such as tempol may provide neuroprotection and improve lifespan. We investigated whether tempol (50 mg/kg) presents therapeutic potenti...

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Bibliographic Details
Main Authors: Gabriela Bortolança Chiarotto, Luciana Politti Cartarozzi, Matheus Perez, Natalia Perussi Biscola, Aline Barroso Spejo, Fernanda Gubert, Marcondes França Junior, Rosália Mendez-Otero, Alexandre Leite Rodrigues de Oliveira
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Amyotrophic lateral sclerosis
Neuroinflammation
Tempol
ALS therapy
Online Access:http://link.springer.com/article/10.1186/s12974-019-1598-x

Internet

http://link.springer.com/article/10.1186/s12974-019-1598-x

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