Generation of active protein phosphatase 2A is coupled to holoenzyme assembly.

Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute a risk to the cell. While it has been assumed...

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Bibliographic Details
Main Authors: Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1885835?pdf=render