Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, inc...

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Main Authors: Min Tian, Yingao Qi, Xiaoli Zhang, Zhihui Wu, Jiaming Chen, Fang Chen, Wutai Guan, Shihai Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Stat5
JAK2
signaling molecules
milk production
mammary gland development
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.604896/full
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spelling doaj-ae7cf13544ce4c1ba29a8f132242c2e92020-11-25T04:06:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-11-01810.3389/fcell.2020.604896604896Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary GlandMin Tian0Yingao Qi1Xiaoli Zhang2Zhihui Wu3Jiaming Chen4Fang Chen5Fang Chen6Fang Chen7Wutai Guan8Wutai Guan9Wutai Guan10Shihai Zhang11Shihai Zhang12Shihai Zhang13Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, ChinaGuangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, ChinaGuangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, ChinaGuangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, ChinaGuangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, ChinaJanus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion.https://www.frontiersin.org/articles/10.3389/fcell.2020.604896/fullStat5JAK2signaling moleculesmilk productionmammary gland development
collection DOAJ
language English
format Article
sources DOAJ
author Min Tian
Yingao Qi
Xiaoli Zhang
Zhihui Wu
Jiaming Chen
Fang Chen
Fang Chen
Fang Chen
Wutai Guan
Wutai Guan
Wutai Guan
Shihai Zhang
Shihai Zhang
Shihai Zhang
spellingShingle Min Tian
Yingao Qi
Xiaoli Zhang
Zhihui Wu
Jiaming Chen
Fang Chen
Fang Chen
Fang Chen
Wutai Guan
Wutai Guan
Wutai Guan
Shihai Zhang
Shihai Zhang
Shihai Zhang
Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
Frontiers in Cell and Developmental Biology
Stat5
JAK2
signaling molecules
milk production
mammary gland development
author_facet Min Tian
Yingao Qi
Xiaoli Zhang
Zhihui Wu
Jiaming Chen
Fang Chen
Fang Chen
Fang Chen
Wutai Guan
Wutai Guan
Wutai Guan
Shihai Zhang
Shihai Zhang
Shihai Zhang
author_sort Min Tian
title Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_short Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_full Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_fullStr Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_full_unstemmed Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_sort regulation of the jak2-stat5 pathway by signaling molecules in the mammary gland
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2020-11-01
description Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion.
topic Stat5
JAK2
signaling molecules
milk production
mammary gland development
url https://www.frontiersin.org/articles/10.3389/fcell.2020.604896/full
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