Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson’s Disease

Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson’s Disease

Parkinson’s disease (PD) is considered the most common disorder of synucleinopathy, which is characterised by intracellular inclusions of aggregated and misfolded α-synuclein (α-syn) protein in various brain regions, and the loss of dopaminergic neurons. During the early prodromal phase of PD, synap...

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Bibliographic Details
Main Authors: Antonella Cardinale, Valeria Calabrese, Antonio de Iure, Barbara Picconi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
synaptopathy
α-synuclein
dopamine
neuroinflammation
immune system
Online Access:https://www.mdpi.com/1422-0067/22/12/6517

Internet

https://www.mdpi.com/1422-0067/22/12/6517

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