P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with elec...

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Bibliographic Details
Main Authors: Verónica Latapiat, Felipe E. Rodríguez, Francisca Godoy, Felipe A. Montenegro, Nelson P. Barrera, Juan P. Huidobro-Toro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
P2X4R
positive allosteric modulation
ivermectin
Zn(II)
molecular docking
molecular dynamics
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00918/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00918/full

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