Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients
Purpose. This study aimed to characterize breakthrough pain (BTP) and investigate its impact on quality-of-life (QoL) in terminally-ill cancer patients. Similarities and differences between high and low predictable BTP were also tested. Methods. Secondary analysis of a multicenter longitudinal obser...
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2019-06-01
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Online Access: | https://doi.org/10.1177/1534735419859095 |
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doaj-aeed853548474a99be575ed5c8c286152020-11-25T04:02:52ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2019-06-011810.1177/1534735419859095Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer PatientsSilvia Gonella RN, MSc, PhD0Riccardo Sperlinga RN, MSc1Veronica Sciannameo MSc, PhD2Valerio Dimonte PhD3Sara Campagna PhD4Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Torino, Torino, ItalyCatholic University of the Sacred Heart, Torino, ItalyUniversity of Padova, ItalyUniversity of Torino, ItalyUniversity of Torino, ItalyPurpose. This study aimed to characterize breakthrough pain (BTP) and investigate its impact on quality-of-life (QoL) in terminally-ill cancer patients. Similarities and differences between high and low predictable BTP were also tested. Methods. Secondary analysis of a multicenter longitudinal observational study included 92 patients at their end-of-life. BTP was assessed with a short form of the Italian version of the Alberta Breakthrough Pain Assessment Tool. QoL was assessed with the Palliative Outcome Scale (0-40). Patients were stratified by self-reported BTP predictability into unpredictable BTP (never or rarely able to predict BTP) and predictable BTP (sometimes to always able to predict BTP). Results. In all, 665 BTP episodes were recorded (median 0.86 episodes/day). A median duration of 30 minutes and a median peak intensity score of 7 out of 10 were reported. Time to peak was <10 minutes, 10 to 30 minutes, and ≥30 minutes in 267 (41.1%), 259 (39.9%), and 30 (4.6%) of the episodes, respectively. Onset of relief occurred after a median of 30 minutes. Time to peak ( P < .001) and duration ( P = .046) of BTP was shorter in patients with predictable pain ( n = 31), who usually were younger than those with unpredictable pain ( P = .03). The mean (SD) QoL score was 14.6 (4.6). No difference in QoL between patients with predictable and unpredictable BTP was found ( P = .49). Conclusions. In terminally-ill cancer patients, BTP is a severe problem with a negative impact on QoL and has different characteristics according to its predictability.https://doi.org/10.1177/1534735419859095 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Silvia Gonella RN, MSc, PhD Riccardo Sperlinga RN, MSc Veronica Sciannameo MSc, PhD Valerio Dimonte PhD Sara Campagna PhD |
spellingShingle |
Silvia Gonella RN, MSc, PhD Riccardo Sperlinga RN, MSc Veronica Sciannameo MSc, PhD Valerio Dimonte PhD Sara Campagna PhD Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients Integrative Cancer Therapies |
author_facet |
Silvia Gonella RN, MSc, PhD Riccardo Sperlinga RN, MSc Veronica Sciannameo MSc, PhD Valerio Dimonte PhD Sara Campagna PhD |
author_sort |
Silvia Gonella RN, MSc, PhD |
title |
Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients |
title_short |
Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients |
title_full |
Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients |
title_fullStr |
Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients |
title_full_unstemmed |
Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients |
title_sort |
characteristics of breakthrough pain and its impact on quality of life in terminally ill cancer patients |
publisher |
SAGE Publishing |
series |
Integrative Cancer Therapies |
issn |
1552-695X |
publishDate |
2019-06-01 |
description |
Purpose. This study aimed to characterize breakthrough pain (BTP) and investigate its impact on quality-of-life (QoL) in terminally-ill cancer patients. Similarities and differences between high and low predictable BTP were also tested. Methods. Secondary analysis of a multicenter longitudinal observational study included 92 patients at their end-of-life. BTP was assessed with a short form of the Italian version of the Alberta Breakthrough Pain Assessment Tool. QoL was assessed with the Palliative Outcome Scale (0-40). Patients were stratified by self-reported BTP predictability into unpredictable BTP (never or rarely able to predict BTP) and predictable BTP (sometimes to always able to predict BTP). Results. In all, 665 BTP episodes were recorded (median 0.86 episodes/day). A median duration of 30 minutes and a median peak intensity score of 7 out of 10 were reported. Time to peak was <10 minutes, 10 to 30 minutes, and ≥30 minutes in 267 (41.1%), 259 (39.9%), and 30 (4.6%) of the episodes, respectively. Onset of relief occurred after a median of 30 minutes. Time to peak ( P < .001) and duration ( P = .046) of BTP was shorter in patients with predictable pain ( n = 31), who usually were younger than those with unpredictable pain ( P = .03). The mean (SD) QoL score was 14.6 (4.6). No difference in QoL between patients with predictable and unpredictable BTP was found ( P = .49). Conclusions. In terminally-ill cancer patients, BTP is a severe problem with a negative impact on QoL and has different characteristics according to its predictability. |
url |
https://doi.org/10.1177/1534735419859095 |
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