On the role of extrinsic noise in microRNA-mediated bimodal gene expression.

Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Bimodal distributions of gene expression levels provide experimental evidence of phenotypic differentiation, where the modes of the distribution often correspond to...

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Bibliographic Details
Main Authors: Marco Del Giudice, Stefano Bo, Silvia Grigolon, Carla Bosia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006063