Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats
Background: Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl2) induced testi...
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doaj-af37d4df69ea44f8bbf4c843ca12ac882021-04-02T13:18:38ZengElsevierBiomedical Journal2319-41702020-04-01432174182Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar ratsSunday Aderemi Adelakun0Victor Okoliko Ukwenya1Grace Temitope Akingbade2Olusegun Dare Omotoso3Julius Akomaye Aniah4Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria; Corresponding author. Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Futa Rd, PMB 704, Akure, Nigeria.Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, NigeriaDepartment of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, NigeriaDepartment of Anatomy, Kogi State University, Anyigba, Kogi State, NigeriaDepartment of Anatomy, College of Medicine, University of Abuja, Federal Capital Territory (FCT), NigeriaBackground: Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl2) induced testicular toxicity in adult male Wistar rats. Methods: Thirty-two adult male Wistar rats were randomly divided into four groups (A-D) of eight (n = 8) rats each. Group A Served as control and was given 10 ml/kg/day of distilled water, Group B- 500 mg/kg B.W of SM, Group C received 40 mg/kg B.W HgCl2 and Group D- 500 mg/kg B.W of SM and 40 mg/kg B.W HgCl2). The administration was done by gastric gavage once a day, for twenty-eight consecutive days. Testicular weight, semen analysis revealing the sperm count and sperm motility were assessed, gross parameters of the testis and testicular histology were assessed. Testicular oxidative stress markers viz a viz malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were also assessed. Results: assessment of the histological profiles of the testes showed a derangement of the cytoarchitecture and deterioration of sperm quality after HgCl2 administration and a marked improvement was observed after SM administration. Similarly, SM was associated with increased antioxidant parameters (SOD, CAT, GPx, and GSH) and decreased MDA in SM + HgCl2 rats. Conclusion: It was concluded that S. melongena offers protection against free radical mediated oxidative stress of rats with mercury chloride induced testicular toxicity.http://www.sciencedirect.com/science/article/pii/S2319417019304755TestisGarden eggsSolanum melongenaMercury chloride |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sunday Aderemi Adelakun Victor Okoliko Ukwenya Grace Temitope Akingbade Olusegun Dare Omotoso Julius Akomaye Aniah |
spellingShingle |
Sunday Aderemi Adelakun Victor Okoliko Ukwenya Grace Temitope Akingbade Olusegun Dare Omotoso Julius Akomaye Aniah Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats Biomedical Journal Testis Garden eggs Solanum melongena Mercury chloride |
author_facet |
Sunday Aderemi Adelakun Victor Okoliko Ukwenya Grace Temitope Akingbade Olusegun Dare Omotoso Julius Akomaye Aniah |
author_sort |
Sunday Aderemi Adelakun |
title |
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats |
title_short |
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats |
title_full |
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats |
title_fullStr |
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats |
title_full_unstemmed |
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats |
title_sort |
interventions of aqueous extract of solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male wistar rats |
publisher |
Elsevier |
series |
Biomedical Journal |
issn |
2319-4170 |
publishDate |
2020-04-01 |
description |
Background: Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl2) induced testicular toxicity in adult male Wistar rats. Methods: Thirty-two adult male Wistar rats were randomly divided into four groups (A-D) of eight (n = 8) rats each. Group A Served as control and was given 10 ml/kg/day of distilled water, Group B- 500 mg/kg B.W of SM, Group C received 40 mg/kg B.W HgCl2 and Group D- 500 mg/kg B.W of SM and 40 mg/kg B.W HgCl2). The administration was done by gastric gavage once a day, for twenty-eight consecutive days. Testicular weight, semen analysis revealing the sperm count and sperm motility were assessed, gross parameters of the testis and testicular histology were assessed. Testicular oxidative stress markers viz a viz malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were also assessed. Results: assessment of the histological profiles of the testes showed a derangement of the cytoarchitecture and deterioration of sperm quality after HgCl2 administration and a marked improvement was observed after SM administration. Similarly, SM was associated with increased antioxidant parameters (SOD, CAT, GPx, and GSH) and decreased MDA in SM + HgCl2 rats. Conclusion: It was concluded that S. melongena offers protection against free radical mediated oxidative stress of rats with mercury chloride induced testicular toxicity. |
topic |
Testis Garden eggs Solanum melongena Mercury chloride |
url |
http://www.sciencedirect.com/science/article/pii/S2319417019304755 |
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